Combining ATR Suppression With Oncogenic Ras Synergistically Increases Genomic Instability, Causing Synthetic Lethality or Tumorigenesis in a Dosage-Dependent Manner

Cancer Research - United States
doi 10.1158/0008-5472.can-10-2286
Full Text
Abstract

Available in full text

Date
Authors
Publisher

American Association for Cancer Research (AACR)

Related search

Oncogenic K-Ras Regulates Bioactive Sphingolipids in a Sphingosine Kinase 1-Dependent Manner

Journal of Biological Chemistry
BiochemistryCell BiologyMolecular Biology
2012English

Cancer-Specific Synthetic Lethality Between ATR and CHK1 Kinase Activities

Cell Reports
BiochemistryGeneticsMolecular Biology
2016English

RAS Promotes Tumorigenesis Through Genomic Instability Induced by Imbalanced Expression of Aurora-A and BRCA2 in Midbody During Cytokinesis

International Journal of Cancer
Cancer ResearchOncology
2013English

Activated K-Ras, but Not H-Ras or N-Ras, Regulates Brain Neural Stem Cell Proliferation in a Raf/Rb-Dependent Manner

Stem Cells
MedicineMolecular MedicineDevelopmental BiologyCell Biology
2015English

Sprouty-2 Regulates Oncogenic K-Ras in Lung Development and Tumorigenesis

Genes and Development
GeneticsDevelopmental Biology
2007English

Oncogenic Ras-Induced Secretion of IL6 Is Required for Tumorigenesis

Genes and Development
GeneticsDevelopmental Biology
2007English

Design and Synthesis of Pictet–Spengler Condensation Products That Exhibit Oncogenic-Ras Synthetic Lethality and Induce Non-Apoptotic Cell Death

Bioorganic and Medicinal Chemistry Letters
Organic ChemistryMolecular MedicineMolecular BiologyBiochemistryClinical BiochemistryPharmaceutical ScienceDrug Discovery
2012English

Iron Modulates Cell Survival in a Ras- And MAPK-dependent Manner in Ovarian Cells

Cell Death and Disease
Molecular NeuroscienceImmunologyCell BiologyCancer ResearchCellularMedicine
2013English

Targeting Oncogenic Ras

Genes and Development
GeneticsDevelopmental Biology
2007English

Amanote Research

Note-taking for researchers

Follow Amanote

© 2024 Amaplex Software S.P.R.L. All rights reserved.

Privacy PolicyRefund Policy