McL-1 Down-Regulation Potentiates ABT-737 Lethality by Cooperatively Inducing Bak Activation and Bax Translocation

Cancer Research- United States

doi 10.1158/0008-5472.can-06-3964

Full Text

Abstract

Available in

Date

Authors

Publisher

American Association for Cancer Research (AACR)

Related search

Ectopic Overexpression of LAPTM5 Results in Lysosomal Targeting and Induces McL-1 Down-Regulation, Bak Activation, and Mitochondria-Dependent Apoptosis in Human HeLa Cells

PLoS ONE
Multidisciplinary
2017English

Glycolysis Inhibition Targets McL-1 to Restore Sensitivity of Lymphoma Cells to ABT-737-induced Apoptosis

Leukemia
Cancer ResearchOncologyAnesthesiologyPain MedicineHematology
2011English

McL-1 and BCL-xL Regulate Bak/Bax-Dependent Apoptosis of the Megakaryocytic Lineage at Multistages

Cell Death and Differentiation
Cell BiologyMolecular Biology
2012English

Greasing the Path to BAX/BAK Activation

Cell
BiochemistryGeneticsMolecular Biology
2012English

Quercetin Induces Tumor-Selective Apoptosis Through Downregulation of McL-1 and Activation of Bax

Clinical Cancer Research
Cancer ResearchOncology
2010English

Synergistic BCL-2 Inhibition by ABT-737 and Cyclosporine A

Apoptosis : an international journal on programmed cell death
Cell BiologyPharmacologyBiochemistryClinical BiochemistryCancer ResearchPharmaceutical Science
2012English

Chemotherapeutic Drugs Sensitize Human Renal Cell Carcinoma Cells to ABT-737 by a Mechanism Involving the Noxa-Dependent Inactivation of McL-1 or A1

Molecular Cancer
Cancer ResearchOncologyMolecular Medicine
2010English

Nutlin-3 Protects Kidney Cells During Cisplatin Therapy by Suppressing Bax/Bak Activation

Journal of Biological Chemistry
BiochemistryCell BiologyMolecular Biology
2006English

Regulation of Neutrophil Apoptosis by McL-1

Biochemical Society Transactions
Biochemistry
2004English

Amanote Research

Note-taking for researchers

Follow Amanote

© 2026 Amaplex Software S.P.R.L. All rights reserved.

Privacy PolicyRefund Policy