Synthesis and in Vitro Cytotoxicity of the 4-(Halogenoanilino)-6-Bromoquinazolines and Their 6-(4-Fluorophenyl) Substituted Derivatives as Potential Inhibitors of Epidermal Growth Factor Receptor Tyrosine Kinase

Pharmaceuticals- Switzerland

doi 10.3390/ph10040087

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Abstract

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Date

November 20, 2017

Authors

Malose Mphahlele

Hugues Paumo

Yee Choong

Publisher

MDPI AG

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Synthesis and in Vitro Cytotoxicity of the 4-(Halogenoanilino)-6-Bromoquinazolines and Their 6-(4-Fluorophenyl) Substituted Derivatives as Potential Inhibitors of Epidermal Growth Factor Receptor Tyrosine Kinase

Pharmaceuticals- Switzerland

Full Text

Abstract

Categories

Date

Authors

Publisher

Related search

Benzofuran–appended 4-Aminoquinazoline Hybrids as Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors: Synthesis, Biological Evaluation and Molecular Docking Studies

Synthesis and Antiproliferative Activities Against Hep-G2 of Salicylanide Derivatives: Potent Inhibitors of the Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase

In Silico Identification of Peptide as Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Lung Cancer Treatment

Structure-Based Design and Synthesis of 3Amino-1,5-Dihydro4Hpyrazolopyridin-4-One Derivatives as Tyrosine Kinase 2 Inhibitors

Complex Epidermal Growth Factor Receptor Mutations and Their Responses to Tyrosine Kinase Inhibitors in Previously Untreated Advanced Lung Adenocarcinomas

Impact of Epidermal Growth Factor Receptor Gene Expression Level on Clinical Outcomes in Epidermal Growth Factor Receptor Mutant Lung Adenocarcinoma Patients Taking First-Line Epidermal Growth Factor Receptor–tyrosine Kinase Inhibitors

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors vs Conventional Chemotherapy in Non–Small Cell Lung Cancer Harboring Wild-Type Epidermal Growth Factor Receptor

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Association of Initial Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors Treatment and EGFR Exon 19 Deletion With Frequency of the T790M Mutation in Non-Small Cell Lung Cancer Patients After Resistance to First-Line Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors