3′-Fluoro Substitution in the Pyridine Ring of Epibatidine Improves Selectivity and Efficacy for Α4β2 Versus Α3β4 nAChRs

Neuropharmacology - United Kingdom
doi 10.1016/j.neuropharm.2008.08.007
Full Text
Abstract

Available in full text

Date
Authors
Publisher

Elsevier BV

Related search

Epibatidine Induces Long-Term Potentiation (LTP) via Activation of Α4β2 Nicotinic Acetylcholine Receptors (nAChRs) in Vivo in the Intact Mouse Dentate Gyrus: Both Α7 and Α4β2 nAChRs Essential to Nicotinic LTP

Journal of Pharmacological Sciences
Molecular MedicinePharmacology
2003English

Functional Characterization of AT-1001, an Α3β4 Nicotinic Acetylcholine Receptor Ligand, at Human Α3β4 and Α4β2 nAChR

Nicotine and Tobacco Research
EnvironmentalPublic HealthOccupational Health
2014English

Pharmacological and Functional Comparisons of Α6/Α3β2β3-nAChRs and Α4β2-nAChRs Heterologously Expressed in the Human Epithelial SH-EP1 Cell Line

Acta Pharmacologica Sinica
MedicinePharmacology
2018English

Selectivity of ABT-089 for Α4β2* and Α6β2* Nicotinic Acetylcholine Receptors in Brain

Biochemical Pharmacology
BiochemistryPharmacology
2009English

Synthesis and Nucleophilic Aromatic Substitution of 3-Fluoro-5-Nitro-1-(Pentafluorosulfanyl)benzene

Beilstein Journal of Organic Chemistry
Organic Chemistry
2016English

Asymmetric Agonist Selectivity of Agonist Sites in (Α4β2)2α4 Nicotinic Acetylcholine Receptors: A Key Determinant of Agonist Efficacy

Biophysical Journal
Biophysics
2014English

[3H]Epibatidine Photolabels Non-Equivalent Amino Acids in the Agonist Binding Site ofTorpedoand Α4β2 Nicotinic Acetylcholine Receptors

Journal of Biological Chemistry
BiochemistryCell BiologyMolecular Biology
2009English

L-Histidinol Improves the Selectivity and Efficacy of Alkylating Agents and Daunomycin in Mice With P388 Leukaemia

British Journal of Cancer
Cancer ResearchOncology
1989English

Synthesis and Evaluation of 3-123i-Iodo-5-[2-(S)-3-Pyrrolinylmethoxy]-Pyridine (Niodene) as a Potential Nicotinic Α4β2 Receptor Imaging Agent

Bioorganic and Medicinal Chemistry Letters
Organic ChemistryMolecular MedicineMolecular BiologyBiochemistryClinical BiochemistryPharmaceutical ScienceDrug Discovery
2012English

Amanote Research

Note-taking for researchers

Follow Amanote

© 2024 Amaplex Software S.P.R.L. All rights reserved.

Privacy PolicyRefund Policy