Compartment-Dependent Degradation of Mutant Huntingtin Accounts for Its Preferential Accumulation in Neuronal Processes

Journal of Neuroscience - United States
doi 10.1523/jneurosci.0806-16.2016
Full Text
Abstract

Available in full text

Categories
Neuroscience
Date
Authors
Publisher

Society for Neuroscience

Related search

Genistein Induces Degradation of Mutant Huntingtin in Fibroblasts From Huntington’s Disease Patients

Metabolic Brain Disease
BiochemistryMolecular NeuroscienceNeurologyCellular
2019English

PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington’s Disease-Associated Phenotypes in Vivo

Neuron
Neuroscience
2016English

Neuronal Targets for Reducing Mutant Huntingtin Expression to Ameliorate Disease in a Mouse Model of Huntington's Disease

Nature Medicine
BiochemistryMedicineGeneticsMolecular Biology
2014English

Degradation of Mutant Huntingtin via the Ubiquitin/Proteasome System Is Modulated by FE65

Biochemical Journal
BiochemistryCell BiologyMolecular Biology
2012English

Caspase-6-Resistant Mutant Huntingtin Does Not Rescue the Toxic Effects of Caspase-Cleavable Mutant Huntingtin in Vivo

Journal of Huntington's disease
Molecular NeuroscienceNeurologyCellular
2012English

A Compartment Size-Dependent Selective Threshold Limits Mutation Accumulation in Hierarchical Tissues

Proceedings of the National Academy of Sciences of the United States of America
Multidisciplinary
2020English

Mutant Huntingtin Forms in Vivo Complexes With Distinct Context-Dependent Conformations of the Polyglutamine Segment

Neurobiology of Disease
Neurology
1999English

Mutant Huntingtin Disrupts the Nuclear Pore Complex

Neuron
Neuroscience
2017English

The Huntingtin Inclusion Is a Dynamic Phase-Separated Compartment

Life Science Alliance
Plant ScienceEcologyGeneticsMolecular BiologyBiochemistryMutagenesisHealthToxicology
2019English

Amanote Research

Note-taking for researchers

Follow Amanote

© 2025 Amaplex Software S.P.R.L. All rights reserved.

Privacy PolicyRefund Policy