Discovery of (R)-6-(1-(8-Fluoro-6-(1-Methyl-1h-Pyrazol-4-Yl)-[1,2,4]triazolo[4,3-A]pyridin-3-Yl)ethyl)-3-(2-Methoxyethoxy)-1,6-Naphthyridin-5(6h)-One (AMG 337), a Potent and Selective Inhibitor of MET With High Unbound Target Coverage and Robust in Vivo Antitumor Activity

Journal of Medicinal Chemistry - United States
doi 10.1021/acs.jmedchem.5b01716
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American Chemical Society (ACS)

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