(PDF) Altered Conformational Landscape and Dimerization

Altered Conformational Landscape and Dimerization Dependency Underpins the Activation of EGFR byαC–β4 Loop Insertion Mutations

Proceedings of the National Academy of Sciences of the United States of America - United States

doi 10.1073/pnas.1803152115

Full Text

Abstract

Available in full text

Categories

Multidisciplinary

Date

August 13, 2018

Authors

Natarajan Kannan

Publisher

Proceedings of the National Academy of Sciences

Related search

MET-EGFR Dimerization in Lung Adenocarcinoma Is Dependent on EGFR Mtations and Altered by MET Kinase Inhibition

Multidisciplinary

English

Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2

Cancer Research

English

Molecular Context of the EGFR Mutations: Evidence for the Activation of mTOR/S6K Signaling

Clinical Cancer Research

Cancer Research

English

Activation of the BMP-BMPR Pathway Conferred Resistance to EGFR-TKIs in Lung Squamous Cell Carcinoma Patients With EGFR Mutations

Proceedings of the National Academy of Sciences of the United States of America

Multidisciplinary

English

P1.13-14 the Molecular Landscape of Lung Adenocarcinomas With Activating EGFR Gene Mutations Determined by Targeted-Sequencing

Journal of Thoracic Oncology

Respiratory Medicine

English

Forced Dimerization Increases the Activity of EGFR/EGFRvIII and Enhances Its Oncogenicity

Molecular Cancer Research

Cancer Research

Molecular Biology

English

Allosteric Control of Human CGAS Dimerization Underpins Its Context-Dependent Response to Cytoplasmic DNA

Biophysical Journal

English

The Proteomic Landscape of Cysteine Oxidation That Underpins Retinoic Acid-Induced Neuronal Differentiation

English

Lovastatin Inhibits EGFR Dimerization and AKT Activation in Squamous Cell Carcinoma Cells: Potential Regulation by Targeting Rho Proteins

Cancer Research

Molecular Biology

English