(PDF) Toward the Design of Mutation-Resistant Enzyme

Toward the Design of Mutation-Resistant Enzyme Inhibitors: Further Evaluation of the Substrate Envelope Hypothesis

Chemical Biology and Drug Design - United Kingdom

doi 10.1111/j.1747-0285.2009.00851.x

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September 1, 2009

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Wiley

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Toward the Design of Mutation-Resistant Enzyme Inhibitors: Further Evaluation of the Substrate Envelope Hypothesis

Chemical Biology and Drug Design - United Kingdom

doi 10.1111/j.1747-0285.2009.00851.x

Full Text

Abstract

Categories

Date

Authors

Publisher

Related search

HIV-1 Protease Inhibitors From Inverse Design in the Substrate Envelope Exhibit Subnanomolar Binding to Drug-Resistant Variants

Involvement of Enzyme-Substrate Charge Interactions in the Caseinolytic Specificity of Lactococcal Cell Envelope-Associated Proteinases.

Further Evaluation of the Tetrodotoxin-Resistant Circadian Pacemaker in the Suprachiasmatic Nuclei

Structure-Based Design, Synthesis, and Biological Evaluation of Non-Acyl Sulfamate Inhibitors of the Adenylate-Forming Enzyme MenE

An Application of Photoactivatable Substrate for the Evaluation of Epithelial-Mesenchymal Transition Inhibitors

HIV1 Protease Inhibitors Incorporating Stereochemically Defined P2 Ligands to Optimize Hydrogen Bonding in the Substrate Envelope

Urinary N-Nitrosoproline Excretion: A Further Evaluation of the Nitrosamine Hypothesis of Gastric Carcinogenesis in Precancerous Conditions.

The Therapeutic Potential of Deubiquitinating Enzyme Inhibitors

DeNovoParallel Design, Synthesis and Evaluation of Inhibitors Against the Reverse Transcriptase of Human Immunodeficiency Virus Type-1 and Drug-Resistant Variants.