The Isoniazid-Nad Adduct Is a Slow, Tight-Binding Inhibitor of InhA, the Mycobacterium Tuberculosis Enoyl Reductase: Adduct Affinity and Drug Resistance

Proceedings of the National Academy of Sciences of the United States of America - United States
doi 10.1073/pnas.2235848100
Full Text
Abstract

Available in full text

Date
Authors
Publisher

Proceedings of the National Academy of Sciences

Related search

Targeting InhA, the FASII Enoyl-Acp Reductase: SAR Studies on Novel Inhibitor Scaffolds

Current Topics in Medicinal Chemistry
MedicineDrug Discovery
2012English

Mycobacterium Tuberculosis Dihydrofolate Reductase Is Not a Target Relevant to the Antitubercular Activity of Isoniazid

Antimicrobial Agents and Chemotherapy
Infectious DiseasesPharmacology
2010English

In Silico Repositioning of Cannabigerol as a Novel Inhibitor of the Enoyl Acyl Carrier Protein (ACP) Reductase (InhA)

Molecules
Organic ChemistryMolecular MedicineAnalytical ChemistryTheoretical ChemistryPharmaceutical ScienceMedicineDrug DiscoveryChemistryPhysical
2019English

Acetylation of Isoniazid - A Novel Mechanism of Isoniazid Resistance in Mycobacterium Tuberculosis

2020English

Drug Resistance of Mycobacterium Tuberculosis

Bulletin of Pharmaceutical Sciences
PharmacologyPharmaceutical Science
2010English

Isoniazid-Induced Transient High-Level Resistance in Mycobacterium Tuberculosis

Antimicrobial Agents and Chemotherapy
Infectious DiseasesPharmacology
2002English

Crystal Structure of L,d-Transpeptidase 3 From Mycobacterium Tuberculosis in Complex With a Faropenem-Derived Adduct

2019English

Binding of Activated Isoniazid With Acetyl-CoA Carboxylase From Mycobacterium Tuberculosis

Bioinformation
2011English

Reactivity of the Drug Methimazole and Its Iodine Adduct With Elemental Zinc

CrystEngComm
Materials ScienceChemistryCondensed Matter Physics
2014English

Amanote Research

Note-taking for researchers

Follow Amanote

© 2024 Amaplex Software S.P.R.L. All rights reserved.

Privacy PolicyRefund Policy