P-Loop Conformation Governed Crizotinib Resistance in G2032r-Mutated ROS1 Tyrosine Kinase: Clues From Free Energy Landscape

PLoS Computational Biology- United States

doi 10.1371/journal.pcbi.1003729

Full Text

Abstract

Available in

Date

Authors

Publisher

Public Library of Science (PLoS)

Related search

The New-Generation Selective ROS1/NTRK Inhibitor DS-6051b Overcomes Crizotinib Resistant ROS1-G2032R Mutation in Preclinical Models

Nature Communications
AstronomyGeneticsMolecular BiologyBiochemistryChemistryPhysics
2019English

Combination of Crizotinib and Osimertinib or Erlotinib Might Overcome MET-Mediated Resistance to EGFR Tyrosine Kinase Inhibitor in EGFR-Mutated Adenocarcinoma

Journal of Thoracic Oncology
MedicineOncologyRespiratory MedicinePulmonary
2018English

Structural Insight Into Selectivity and Resistance Profiles of ROS1 Tyrosine Kinase Inhibitors

Proceedings of the National Academy of Sciences of the United States of America
Multidisciplinary
2015English

P075 Hippo-Yap Pathway Mediated Resistance to Crizotinib in ROS1-Positive Lung Cancer

Journal of Thoracic Oncology
MedicineOncologyRespiratory MedicinePulmonary
2018English

Patients Harboring EGFR Mutation After Primary Resistance to Crizotinib and Response to EGFR-tyrosine Kinase Inhibitor

OncoTargets and Therapy
OncologyPharmacology
2016English

Protein Kinase Free Energy Landscapes: The Role of the Activation Loop

Biophysical Journal
Biophysics
2019English

ALK, ROS1 and EGFR Next-Generation Tyrosine Kinase Inhibitors in Advanced Non-Small-Cell Lung Cancer

Oncology in Clinical Practice
Oncology
2019English

P1.13-23 TP53 Mutations as Mechanisms of Primary and Acquired Resistance to Tyrosine Kinase Inhibitors in Patients With EGFR-Mutated NSCLC

Journal of Thoracic Oncology
MedicineOncologyRespiratory MedicinePulmonary
2018English

Side-Chain Conformation at the Selectivity Filter Shapes the Permeation Free-Energy Landscape of an Ion Channel

Proceedings of the National Academy of Sciences of the United States of America
Multidisciplinary
2014English

Amanote Research

Note-taking for researchers

Follow Amanote

© 2026 Amaplex Software S.P.R.L. All rights reserved.

Privacy PolicyRefund Policy