Structure–Activity Relationship and in Vitro and in Vivo Evaluation of the Potent Cytotoxic Anti-Microtubule AgentN-(4-Methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium Chloride and Its Analogues as Antitumor Agents

Journal of Medicinal Chemistry- United States

doi 10.1021/jm400639z

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August 29, 2013

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American Chemical Society (ACS)

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Structure–Activity Relationship and in Vitro and in Vivo Evaluation of the Potent Cytotoxic Anti-Microtubule AgentN-(4-Methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium Chloride and Its Analogues as Antitumor Agents

Journal of Medicinal Chemistry- United States

Full Text

Abstract

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Date

Authors

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Related search

Synthesis of N-Alkylated Derivatives of 1-(4-Methoxyphenyl)-1,5-Dihydro-4h-Pyrazolo[3,4-D]pyrimidin-4-Ones as Potential Anticonvulsants

Synthesis and Biological Evaluation ofN-[2-(4-Hydroxyphenylamino)-pyridin-3-yl]-4-methoxy-benzenesulfonamide (ABT-751) Tricyclic Analogues as Antimitotic and Antivascular Agents With Potent in Vivo Antitumor Activity

Design and Synthesis of 2-(3-Benzo[b]thienyl)-6,7-Methylenedioxyquinolin-4-One Analogues as Potent Antitumor Agents That Inhibit Tubulin Assembly

Synthesis and Structure-Activity Relationship Study of the Potent Cytotoxic Analogues of the Marine Alkaloid Lamellarin D

Antitumor Agents. 254. Synthesis and Biological Evaluation of Novel Neo-Tanshinlactone Analogues as Potent Anti-Breast Cancer Agents

Antitumor Agents. 272. Structure−Activity Relationships and in Vivo Selective Anti-Breast Cancer Activity of Novel Neo-Tanshinlactone Analogues

6-(4-Chlorophenyl)-2-(4-Methoxyphenyl)-6,7-Dihydro-4h-Pyrazolo[5,1-C][1,4]oxazine

Anticancer Activity Evaluation of New Thieno[2,3-D]pyrimidin-4(3h)-Ones and Thieno[3,2-D]pyrimidin-4(3h)-One Derivatives

Study of Quantitative Structure-Activity Relationship (QSAR) of Diarylaniline Analogues as in Vitro Anti-Hiv-1 Agents in Pharmaceutical Interest