Extrapolation of in Vivo Hepatic Clearance From in Vitro Uptake Clearance by Suspended Human Hepatocytes (IVIVE) for Anionic Drugs With High Binding to Human Albumin: Improvement of IVIVE by Considering the "Albumin-Mediated" Hepatic Uptake Mechanism Based on the Facilitated-Dissociation Model

Drug Metabolism and Disposition - United States

doi 10.1124/dmd.118.083733