(PDF) Oncogenic Mutations Mimic and Enhance Dynamic Events

Oncogenic Mutations Mimic and Enhance Dynamic Events in the Natural Activation of Phosphoinositide 3-Kinase P110 (PIK3CA)

Proceedings of the National Academy of Sciences of the United States of America - United States

doi 10.1073/pnas.1205508109

Full Text

Abstract

Available in full text

Categories

Multidisciplinary

Date

September 4, 2012

Authors

Glenn R. Masson

Roger L. Williams

Publisher

Proceedings of the National Academy of Sciences

Related search

Constitutive Phosphoinositide 3-Kinase Activation in Acute Myeloid Leukemia Is Not Due to P110δ Mutations

Cancer Research

English

Multiple Phosphoinositide 3-Kinase-Dependent Steps in Activation of Protein Kinase B

Molecular and Cellular Biology

Molecular Biology

English

Essential, Nonredundant Role for the Phosphoinositide 3-Kinase P110 in Signaling by the B-Cell Receptor Complex

Molecular and Cellular Biology

Molecular Biology

English

Targeting the Phosphoinositide 3-Kinase P110- Isoform Impairs Cell Proliferation, Survival, and Tumor Growth in Small Cell Lung Cancer

Clinical Cancer Research

Cancer Research

English

Gβγ Stimulates Phosphoinositide 3-Kinase-Γ by Direct Interaction With Two Domains of the Catalytic P110 Subunit

Journal of Biological Chemistry

Molecular Biology

English

Phosphatidylinositol 3-Kinase Mutations Identified in Human Cancer Are Oncogenic

Proceedings of the National Academy of Sciences of the United States of America

Multidisciplinary

English

Phosphoinositide 3-Kinase Mutations in Breast Cancer: A "Good" Activating Mutation?

Clinical Cancer Research

Cancer Research

English

Molecular Mechanisms of Human Disease Mediated by Oncogenic and Primary Immunodeficiency Mutations in Class IA Phosphoinositide 3-Kinases

Frontiers in Immunology

English

Phosphoinositide 3-Kinase Inhibitors in Lymphoma

Current Opinion in Oncology

Cancer Research

English