Sequential Addition of Temperature-Sensitive Missense Mutations Into the PB2 Gene of Influenza a Transfectant Viruses Can Effect an Increase in Temperature Sensitivity and Attenuation and Permits the Rational Design of a Genetically Engineered Live Influenza a Virus Vaccine.
Journal of Virology - United States
doi 10.1128/jvi.69.10.5969-5977.1995
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Date
January 1, 1995
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American Society for Microbiology