Mutation of Cysteine Residue 455 to Alanine in Human Topoisomerase IIα Confers Hypersensitivity to Quinones: Enhancing DNA Scission by Closing the N-Terminal Protein Gate†

Chemical Research in Toxicology - United States
doi 10.1021/tx700062t
Full Text
Abstract

Available in full text

Date
Authors
Publisher

American Chemical Society (ACS)

Related search

BAF Complexes Facilitate Decatenation of DNA by Topoisomerase IIα

Nature
Multidisciplinary
2013English

The P53 Tumor Suppressor Stimulates the Catalytic Activity of Human Topoisomerase IIα by Enhancing the Rate of ATP Hydrolysis

Journal of Biological Chemistry
BiochemistryCell BiologyMolecular Biology
2000English

The Role of an Inverted CCAAT Element in Transcriptional Activation of the Human DNA Topoisomerase IIα Gene by Heat Shock

Journal of Biological Chemistry
BiochemistryCell BiologyMolecular Biology
1998English

Conserved Cysteine Residue in the DNA-binding Domain of the Bovine Papillomavirus Type 1 E2 Protein Confers Redox Regulation of the DNA-binding Activity in Vitro.

Proceedings of the National Academy of Sciences of the United States of America
Multidisciplinary
1992English

Proteasomal Inhibition Stabilizes Topoisomerase IIα Protein and Reverses Resistance to the Topoisomerase II Poison Ethonafide (AMP-53, 6-Ethoxyazonafide)

Biochemical Pharmacology
BiochemistryPharmacology
2008English

The Human Papillomavirus Confers Radiosensitivity in Oropharyngeal Cancer Cells by Enhancing DNA Double Strand Break

Oncotarget
Oncology
2020English

Coordinating the Two Protomer Active Sites of Human Topoisomerase IIα: Nicks as Topoisomerase II Poisons†

Biochemistry
Biochemistry
2009English

Quantitative Immunocytochemical Assays of Topoisomerase II in Lung Adenocarcinoma Cell Lines : Correlation to Topoisomerase IIα Content and Topoisomerase II Catalytic Activity

Acta Oncologica
Nuclear MedicineRadiologyHematologyOncologyMedicineImaging
1996English

Doxorubicin‐induced Cardiotoxicity Is Maturation Dependent Due to the Shift From Topoisomerase IIα to IIβ in Human Stem Cell Derived Cardiomyocytes

Journal of Cellular and Molecular Medicine
Molecular MedicineCell Biology
2019English

Amanote Research

Note-taking for researchers

Follow Amanote

© 2026 Amaplex Software S.P.R.L. All rights reserved.

Privacy PolicyRefund Policy