Discovery of 5-Substituted Pyrrolo[2,3-D]pyrimidine Antifolates as Dual-Acting Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase in De Novo Purine Nucleotide Biosynthesis: Implications of Inhibiting 5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase to AMPK Activation and Antitumor Activity

Journal of Medicinal Chemistry - United States
doi 10.1021/jm401328u
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American Chemical Society (ACS)

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