(PDF) Harnessing Nature’s Insight: Design of Aspartyl

Harnessing Nature’s Insight: Design of Aspartyl Protease Inhibitors From Treatment of Drug-Resistant HIV to Alzheimer’s Disease†

Journal of Medicinal Chemistry - United States

doi 10.1021/jm900064c

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Abstract

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Date

April 23, 2009

Authors

Arun K. Ghosh

Publisher

American Chemical Society (ACS)

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Harnessing Nature’s Insight: Design of Aspartyl Protease Inhibitors From Treatment of Drug-Resistant HIV to Alzheimer’s Disease†

Journal of Medicinal Chemistry - United States

doi 10.1021/jm900064c

Full Text

Abstract

Categories

Date

Authors

Publisher

Related search

HIV-1 Protease Inhibitors From Inverse Design in the Substrate Envelope Exhibit Subnanomolar Binding to Drug-Resistant Variants

Structure-Based Design of Novel HIV-1 Protease Inhibitors to Combat Drug Resistance

Lack of Synergy for Inhibitors Targeting a Multi-Drug Resistant Hiv-1 Protease

Interactions of Different Inhibitors With Active-Site Aspartyl Residues of HIV-1 Protease and Possible Relevance to Pepsin

187 Drug Resistance: Crystallography of Drug-Resistant HIV-1 Protease Mutant

Design, Synthesis, and Biological and Structural Evaluations of Novel HIV-1 Protease Inhibitors to Combat Drug Resistance

Novel Central Nervous System (CNS)-Targeting Protease Inhibitors for Drug-Resistant HIV Infection and HIV-Associated CNS Complications

HIV-protease Inhibitors for the Treatment of Cancer: Repositioning HIV Protease Inhibitors While Developing More Potent NO-hybridized Derivatives?

In Vitro Selection and Characterization of Human Immunodeficiency Virus Type 1 (HIV-1) Isolates With Reduced Sensitivity to Hydroxyethylamino Sulfonamide Inhibitors of HIV-1 Aspartyl Protease.