Carboxylesterase-2 Is a Highly Sensitive Target of the Antiobesity Agent Orlistat With Profound Implications in the Activation of Anticancer Prodrugs

Biochemical Pharmacology - Netherlands
doi 10.1016/j.bcp.2012.11.026
Full Text
Abstract

Available in full text

Date
Authors
Publisher

Elsevier BV

Related search

Multiplicity of Carboxylesterase Isozymes in Mammals and Humans: Role in Metabolic Activation of Prodrugs

Drug Metabolism and Pharmacokinetics
2001English

Organ-Specific Carboxylesterase Profiling Identifies the Small Intestine and Kidney as Major Contributors of Activation of the Anticancer Prodrug CPT-11

Biochemical Pharmacology
BiochemistryPharmacology
2011English

Diacetoxyscirpenol as a New Anticancer Agent to Target Hypoxia-Inducible Factor 1

Oncotarget
Oncology
2016English

Oncogenic microRNA-27a Is a Target for Anticancer Agent Methyl 2-Cyano-3,11-Dioxo-18β-Olean-1,12-Dien-30-Oate in Colon Cancer Cells

International Journal of Cancer
Cancer ResearchOncology
2009English

Carboxylesterase Isoform 2 mRNA Expression in Peripheral Blood Mononuclear Cells Is a Predictive Marker of the Irinotecan to SN38 Activation Step in Colorectal Cancer Patients

Clinical Cancer Research
Cancer ResearchOncology
2005English

Garcinia Cambogia (Hydroxycitric Acid) as a Potential Antiobesity Agent

JAMA - Journal of the American Medical Association
Medicine
1998English

Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation

Drug Metabolism and Disposition
PharmacologyPharmaceutical Science
2016English

Biological Evidences of Hepatocellular Carcinoma Treatment With 1,3,4-Oxadiazole-2-Thiol as Anticancer Agent

Journal of Biomolecular Research & Therapeutics
2017English

Repurposing the Serotonin Agonist Tegaserod as an Anticancer Agent in Melanoma: Molecular Mechanisms and Clinical Implications

Journal of Experimental and Clinical Cancer Research
Cancer ResearchOncology
2020English

Amanote Research

Note-taking for researchers

Follow Amanote

© 2024 Amaplex Software S.P.R.L. All rights reserved.

Privacy PolicyRefund Policy