High-Throughput Screening (HTS) and Hit Validation to Identify Small Molecule Inhibitors With Activity Against NS3/4A Proteases From Multiple Hepatitis C Virus Genotypes

PLoS ONE - United States
doi 10.1371/journal.pone.0075144
Full Text
Abstract

Available in full text

Date
Authors
Publisher

Public Library of Science (PLoS)

Related search

Sensitivity of NS3 Serine Proteases From Hepatitis C Virus Genotypes 2 and 3 to the Inhibitor BILN 2061

Journal of Virology
Insect ScienceImmunologyMicrobiologyVirology
2004English

Small-Molecule Collection and High-Throughput Colorimetric Assay to Identify PARP1 Inhibitors

Methods in Molecular Biology
GeneticsMolecular Biology
2011English

Sequencing Analysis of NS3/4A, NS5A, and NS5B Genes From Patients Infected With Hepatitis C Virus Genotypes 5 and 6

Journal of Clinical Microbiology
Microbiology
2016English

Development of Cell-Based Assays for in Vitro Characterization of Hepatitis C Virus NS3/4A Protease Inhibitors

Antimicrobial Agents and Chemotherapy
Infectious DiseasesPharmacology
2005English

Small Molecule Pan-Dengue and West Nile Virus NS3 Protease Inhibitors

Antiviral Chemistry and Chemotherapy
MedicineVirologyDrug DiscoveryPharmacology
2011English

Combinations of Cyclophilin Inhibitor NIM811 With Hepatitis C Virus NS3-4A Protease or NS5B Polymerase Inhibitors Enhance Antiviral Activity and Suppress the Emergence of Resistance

Antimicrobial Agents and Chemotherapy
Infectious DiseasesPharmacology
2008English

In VitroAntiviral Activity and Resistance Profile of the Next-Generation Hepatitis C Virus NS3/4A Protease Inhibitor Glecaprevir

Antimicrobial Agents and Chemotherapy
Infectious DiseasesPharmacology
2017English

Identification of Small Molecule Inhibitors Targeting the SMARCA2 Bromodomain From a High-Throughput Screening Assay

Acta Pharmacologica Sinica
MedicinePharmacology
2018English

Unraveling the Structural Basis of Grazoprevir Potency Against Clinically Relevant Substitutions in Hepatitis C Virus NS3/4A Protease From Genotype 1a

Journal of Biological Chemistry
BiochemistryCell BiologyMolecular Biology
2017English

Amanote Research

Note-taking for researchers

Follow Amanote

© 2024 Amaplex Software S.P.R.L. All rights reserved.

Privacy PolicyRefund Policy