The E6AP Binding Pocket of the HPV16 E6 Oncoprotein Provides a Docking Site for a Small Inhibitory Peptide Unrelated to E6AP, Indicating Druggability of E6

PLoS ONE - United States
doi 10.1371/journal.pone.0112514
Full Text
Abstract

Available in full text

Date
Authors
Publisher

Public Library of Science (PLoS)

Related search

Small Molecule Inhibitors of the HPV16-E6 Interaction With Caspase 8

Bioorganic and Medicinal Chemistry Letters
Organic ChemistryMolecular MedicineMolecular BiologyBiochemistryClinical BiochemistryPharmaceutical ScienceDrug Discovery
2012English

Human Scribble (Vartul) Is Targeted for Ubiquitin-Mediated Degradation by the High-Risk Papillomavirus E6 Proteins and the E6AP Ubiquitin-Protein Ligase

Molecular and Cellular Biology
Cell BiologyMolecular Biology
2000English

Cloning and Expression of the cDNA for E6-Ap, a Protein That Mediates the Interaction of the Human Papillomavirus E6 Oncoprotein With P53.

Molecular and Cellular Biology
Cell BiologyMolecular Biology
1993English

The HPV16 E6 Oncoprotein Causes Prolonged Receptor Protein Tyrosine Kinase Signaling and Enhances Internalization of Phosphorylated Receptor Species

PLoS Pathogens
ImmunologyMolecular BiologyVirologyMicrobiologyParasitologyGenetics
2013English

USP15 Inhibits HPV16 E6 Degradation and Catalytically Inactive USP15 Has Reduced Inhibitory Activity

Acta Virologica
MedicineVirologyInfectious Diseases
2018English

Sequence Determinants of E2-E6ap Binding Affinity and Specificity

Journal of Molecular Biology
Structural BiologyMolecular BiologyBiophysics
2007English

Structure of E3 Ligase E6AP With a Novel Proteasome-Binding Site Provided by Substrate Receptor hRpn10

2019English

A Quantitative LumiFluo Assay to Test Inhibitory Compounds Blocking P53 Degradation Induced by Human Papillomavirus Oncoprotein E6 in Living Cells

Scientific Reports
Multidisciplinary
2018English

Ubiquitination of Substrates by E6Ap/Ube3a Ligase

Biophysical Journal
Biophysics
2017English

Amanote Research

Note-taking for researchers

Follow Amanote

© 2024 Amaplex Software S.P.R.L. All rights reserved.

Privacy PolicyRefund Policy