Inhibition of BRCT(BRCA1)-phosphoprotein Interaction Enhances the Cytotoxic Effect of Olaparib in Breast Cancer Cells: A Proof of Concept Study for Synthetic Lethal Therapeutic Option

Breast Cancer Research and Treatment - Netherlands
doi 10.1007/s10549-012-2079-4
Full Text
Abstract

Available in full text

Date
Authors
Publisher

Springer Science and Business Media LLC

Related search

Synthetic Lethal Interaction of CDK Inhibition and Autophagy Inhibition in Human Solid Cancer Cell Lines

Oncology Reports
MedicineCancer ResearchOncology
2017English

The PARP Inhibitor AZD2281 (Olaparib) Induces Autophagy/Mitophagy in BRCA1 and BRCA2 Mutant Breast Cancer Cells

International Journal of Oncology
Cancer ResearchOncology
2015English

Synthetic Lethal Interactions Between EGFR and PARP Inhibition in Human Triple Negative Breast Cancer Cells

PLoS ONE
Multidisciplinary
2012English

Polo-Like Kinase 1 Inhibition as a Therapeutic Approach to Selectively Target BRCA1-Deficient Cancer Cells by Synthetic Lethality Induction

Clinical Cancer Research
Cancer ResearchOncology
2019English

Class IIb HDAC Inhibition Enhances the Inhibitory Effect of Am80, a Synthetic Retinoid, in Prostate Cancer

Biological and Pharmaceutical Bulletin
MedicinePharmacologyPharmaceutical Science
2019English

The Synthetic Lethal Killing of RAD54B-deficient Colorectal Cancer Cells by PARP1 Inhibition Is Enhanced With SOD1 Inhibition

Oncotarget
Oncology
2016English

Determination of Synthetic Lethal Interactions in KRAS Oncogene-Dependent Cancer Cells Reveals Novel Therapeutic Targeting Strategies

Cell Research
Cell BiologyMolecular Biology
2012English

Selective Cytotoxic Effect of Plantago Lanceolata L. Against Breast Cancer Cells

Journal of the Egyptian National Cancer Institute
2019English

Synthetic Lethal Interaction of Combined BCL-XL and MEK Inhibition Promotes Tumor Regressions in KRAS Mutant Cancer Models

Cancer Cell
Cancer ResearchOncologyCell Biology
2013English

Amanote Research

Note-taking for researchers

Follow Amanote

© 2025 Amaplex Software S.P.R.L. All rights reserved.

Privacy PolicyRefund Policy