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The MUK Five Protocol: A Phase II Randomised, Controlled, Parallel Group, Multi-Centre Trial of Carfilzomib, Cyclophosphamide and Dexamethasone (CCD) vs. Cyclophosphamide, Bortezomib (Velcade) and Dexamethasone (CVD) for First Relapse and Primary Refractory Multiple Myeloma