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Publications by Dennis J. Selkoe

Direct and Potent Regulation of Γ-Secretase by Its Lipid Microenvironment

Journal of Biological Chemistry

Molecular Biology

English

The Notch Ligands, Jagged and Delta, Are Sequentially Processed by Α-Secretase and Presenilin/Γ-Secretase and Release Signaling Fragments

Journal of Biological Chemistry

Molecular Biology

English

Inhibition of Receptor-Mediated Endocytosis Demonstrates Generation of Amyloid Β-Protein at the Cell Surface

Journal of Biological Chemistry

Molecular Biology

English

LRP Promotes Endocytosis and Degradation, but Not Transcytosis, of the Amyloid-Β Peptide in a Blood–brain Barrier in Vitro Model

Neurobiology of Disease

English

The Intracellular Domain of the Β-Amyloid Precursor Protein Is Stabilized by Fe65 and Translocates to the Nucleus in a Notch-Like Manner

Journal of Biological Chemistry

Molecular Biology

English

The Transmembrane Aspartates in Presenilin 1 and 2 Are Obligatory for Γ-Secretase Activity and Amyloid Β-Protein Generation

Journal of Biological Chemistry

Molecular Biology

English

Loss of Neprilysin Function Promotes Amyloid Plaque Formation and Causes Cerebral Amyloid Angiopathy

American Journal of Pathology

Forensic Medicine

English

A Profile of Impaired Insulin Degradation in Relation to Late-Life Cognitive Decline: A Preliminary Investigation

International Journal of Geriatric Psychiatry

English

Defining Molecular Targets to Prevent Alzheimer Disease

Archives of Neurology

English