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Publications by Douglas J. Sheffler

Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M4)

Journal of Biomolecular Screening
Molecular MedicinePharmacologyBiochemistryAnalytical ChemistryBiotechnologyDrug Discovery
2015English

Development of Novel M1 Antagonist Scaffolds Through the Continued Optimization of the MLPCN Probe ML012

Bioorganic and Medicinal Chemistry Letters
Organic ChemistryMolecular MedicineMolecular BiologyBiochemistryClinical BiochemistryPharmaceutical ScienceDrug Discovery
2012English

Related publications

Antipsychotic-Induced Catalepsy Is Attenuated in Mice Lacking the M4 Muscarinic Acetylcholine Receptor

European Journal of Pharmacology
Pharmacology
2011English

The Muscarinic Acetylcholine Receptor Agonist BuTAC Mediates Antipsychotic-Like Effects via the M4 Subtype

Neuropsychopharmacology
PsychiatryMental HealthPharmacology
2013English

Dysregulated Hippocampal Acetylcholine Neurotransmission and Impaired Cognition in M2, M4 and M2/M4 Muscarinic Receptor Knockout Mice

Molecular Psychiatry
PsychiatryMolecular NeuroscienceMental HealthMolecular BiologyCellular
2003English

Solubilization of the Muscarinic Acetylcholine Receptor by Sodium Cholate: Stabilization of the Receptor by Muscarinic Ligands

Biomedical Research
BiochemistryMedicineGeneticsMolecular Biology
1982English

Discovery and Development of Muscarinic Acetylcholine M4 Activators as Promising Therapeutic Agents for CNS Diseases

Chemical and Pharmaceutical Bulletin
MedicineDrug DiscoveryChemistry
2018English

Identification and Localization of Muscarinic Acetylcholine Receptor Proteins in Brain With Subtype-Specific Antibodies

Journal of Neuroscience
Neuroscience
1991English

Ligand-Binding Propeties of the Muscarinic Acetylcholine Receptor in Mouse Neuroblastoma Cells

Biochemical Journal
BiochemistryCell BiologyMolecular Biology
1978English

In Vivo Determination of Muscarinic Acetylcholine Receptor Availability in Schizophrenia

American Journal of Psychiatry
PsychiatryMental Health
2003English

Modulation of the M2 Muscarinic Acetylcholine Receptor Activity With Monoclonal Anti-M2 Receptor Antibody Fragments

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