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Publications by Haydar Bulut

Halogen Bond Interactions of Novel HIV-1 Protease Inhibitors (PI)(GRL-001-15 and GRL-003-15) With the Flap of Protease Are Critical for Their Potent Activity Against Wild-Type and Multi-Pi-Resistant HIV-1 Variants

Antimicrobial Agents and Chemotherapy

Infectious Diseases

Pharmacology

2019

English

Novel Protease Inhibitors Containing C-5-Modified Bis-THF and Aminobenzothiazole as P2 and P2′ Ligands That Exert Potent Antiviral Activity Against Highly Multidrug-Resistant HIV-1 With High Genetic Barrier Against the Emergence of Drug Resistance.

Antimicrobial Agents and Chemotherapy

Infectious Diseases

Pharmacology

2019

English

Related publications

482 GRL-142, a Novel HIV-1 Protease Inhibitor, Potently Blocks HIV-1 Ex Vivo Infection of Langerhans Cells Within Epithelium

Journal of Investigative Dermatology

English

Intracellular Expression of Human Immunodeficiency Virus Type 1 (HIV-1) Protease Variants Inhibits Replication of Wild-Type and Protease Inhibitor-Resistant HIV-1 Strains in Human T-Cell Lines.

English

Lack of Synergy for Inhibitors Targeting a Multi-Drug Resistant Hiv-1 Protease

2002

English

Figure 2. GRL-142 Has Significantly More Potent HIV-1 Protease Dimerization Inhibition Activity, Much Greater Thermal Stability, and Much Higher Intracellular Concentration Than DRV.

English

Flap-Site Fragment Restores Back Wild-Type Behaviour in Resistant Form of HIV Protease

Molecular Informatics

Organic Chemistry

Drug Discovery

Computer Science Applications

Molecular Medicine

Structural Biology

2018

English

Novel P2 Tris-Tetrahydrofuran Group in Antiviral Compound1(GRL-0519) Fills the S2 Binding Pocket of Selected Mutants of HIV-1 Protease

Journal of Medicinal Chemistry

Drug Discovery

Molecular Medicine

2013

English

Activities of the Human Immunodeficiency Virus Type 1 (HIV-1) Protease Inhibitor Nelfinavir Mesylate in Combination With Reverse Transcriptase and Protease Inhibitors Against Acute HIV-1 Infection in Vitro.

Antimicrobial Agents and Chemotherapy

Infectious Diseases

Pharmacology

1997

English

Solvation Influences Flap Collapse in HIV-1 Protease

Proteins: Structure, Function and Genetics

English

Transition States of Native and Drug-Resistant HIV-1 Protease Are the Same

Proceedings of the National Academy of Sciences of the United States of America

Multidisciplinary

2012

English

Amanote Research

Discover open access scientific publications

Search, annotate, share and cite publications

Publications by Haydar Bulut

Halogen Bond Interactions of Novel HIV-1 Protease Inhibitors (PI)(GRL-001-15 and GRL-003-15) With the Flap of Protease Are Critical for Their Potent Activity Against Wild-Type and Multi-Pi-Resistant HIV-1 Variants

Novel Protease Inhibitors Containing C-5-Modified Bis-THF and Aminobenzothiazole as P2 and P2′ Ligands That Exert Potent Antiviral Activity Against Highly Multidrug-Resistant HIV-1 With High Genetic Barrier Against the Emergence of Drug Resistance.

Related publications

482 GRL-142, a Novel HIV-1 Protease Inhibitor, Potently Blocks HIV-1 Ex Vivo Infection of Langerhans Cells Within Epithelium

Intracellular Expression of Human Immunodeficiency Virus Type 1 (HIV-1) Protease Variants Inhibits Replication of Wild-Type and Protease Inhibitor-Resistant HIV-1 Strains in Human T-Cell Lines.

Lack of Synergy for Inhibitors Targeting a Multi-Drug Resistant Hiv-1 Protease

Figure 2. GRL-142 Has Significantly More Potent HIV-1 Protease Dimerization Inhibition Activity, Much Greater Thermal Stability, and Much Higher Intracellular Concentration Than DRV.

Flap-Site Fragment Restores Back Wild-Type Behaviour in Resistant Form of HIV Protease

Novel P2 Tris-Tetrahydrofuran Group in Antiviral Compound1(GRL-0519) Fills the S2 Binding Pocket of Selected Mutants of HIV-1 Protease

Activities of the Human Immunodeficiency Virus Type 1 (HIV-1) Protease Inhibitor Nelfinavir Mesylate in Combination With Reverse Transcriptase and Protease Inhibitors Against Acute HIV-1 Infection in Vitro.

Solvation Influences Flap Collapse in HIV-1 Protease

Transition States of Native and Drug-Resistant HIV-1 Protease Are the Same