Discover open access scientific publications

Search, annotate, share and cite publications

Publications by Irene T. Weber

Novel P2 Tris-Tetrahydrofuran Group in Antiviral Compound1(GRL-0519) Fills the S2 Binding Pocket of Selected Mutants of HIV-1 Protease

Journal of Medicinal Chemistry

Drug Discovery

Molecular Medicine

2013

English

HIV-1 Protease With 20 Mutations Exhibits Extreme Resistance to Clinical Inhibitors Through Coordinated Structural Rearrangements

Biochemistry

2012

English

Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics

PLoS ONE

Multidisciplinary

2016

English

Potent HIV‐1 Protease Inhibitors Containing Carboxylic and Boronic Acids: Effect on Enzyme Inhibition and Antiviral Activity and Protein‐ligand X‐ray Structural Studies

English

Structural Basis for a Hand-Like Site in the Calcium Sensor CatchER With Fast Kinetics

Acta Crystallographica Section D Biological Crystallography

2013

English

Defining the DNA Substrate Binding Sites on HIV-1 Integrase

Journal of Molecular Biology

English

Mutational Analysis of the Substrate Binding Pocket of Murine Leukemia Virus Protease and Comparison With Human Immunodeficiency Virus Proteases

Journal of Biological Chemistry

English

Flexible Cyclic Ethers/Polyethers as Novel P2-Ligands for HIV-1 Protease Inhibitors: Design, Synthesis, Biological Evaluation, and Protein−Ligand X-Ray Studies†

Journal of Medicinal Chemistry

Drug Discovery

Molecular Medicine

2008

English

Activity of Tethered Human Immunodeficiency Virus 1 Protease Containing Mutations in the Flap Region of One Subunit

English

Highly Conserved Glycine 86 and Arginine 87 Residues Contribute Differently to the Structure and Activity of the Mature HIV-1 Protease

Proteins: Structure, Function and Genetics

English

Amanote Research

Discover open access scientific publications

Search, annotate, share and cite publications

Publications by Irene T. Weber

Novel P2 Tris-Tetrahydrofuran Group in Antiviral Compound1(GRL-0519) Fills the S2 Binding Pocket of Selected Mutants of HIV-1 Protease

HIV-1 Protease With 20 Mutations Exhibits Extreme Resistance to Clinical Inhibitors Through Coordinated Structural Rearrangements

Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics

Potent HIV‐1 Protease Inhibitors Containing Carboxylic and Boronic Acids: Effect on Enzyme Inhibition and Antiviral Activity and Protein‐ligand X‐ray Structural Studies

Structural Basis for a Hand-Like Site in the Calcium Sensor CatchER With Fast Kinetics

Defining the DNA Substrate Binding Sites on HIV-1 Integrase

Mutational Analysis of the Substrate Binding Pocket of Murine Leukemia Virus Protease and Comparison With Human Immunodeficiency Virus Proteases

Flexible Cyclic Ethers/Polyethers as Novel P2-Ligands for HIV-1 Protease Inhibitors: Design, Synthesis, Biological Evaluation, and Protein−Ligand X-Ray Studies†

Activity of Tethered Human Immunodeficiency Virus 1 Protease Containing Mutations in the Flap Region of One Subunit

Highly Conserved Glycine 86 and Arginine 87 Residues Contribute Differently to the Structure and Activity of the Mature HIV-1 Protease