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Publications by James E. Bradner
The Bromodomain Protein Brd4 Insulates Chromatin From DNA Damage Signalling
Nature
Multidisciplinary
Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia
Cancer Discovery
Oncology
Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset
Cancer Discovery
Oncology
HIF Activation Causes Synthetic Lethality Between the VHL Tumor Suppressor and the EZH1 Histone Methyltransferase
Science Translational Medicine
Medicine
Phenothiazines Induce PP2A-mediated Apoptosis in T Cell Acute Lymphoblastic Leukemia
Journal of Clinical Investigation
Medicine
Hotspots of Aberrant Enhancer Activity Punctuate the Colorectal Cancer Epigenome
Nature Communications
Astronomy
Genetics
Molecular Biology
Biochemistry
Chemistry
Physics
Enhancer Domains in Gastrointestinal Stromal Tumor Regulate KIT Expression and Are Targetable by BET Bromodomain Inhibition
Cancer Research
Cancer Research
Oncology
Highly Active Combination of BRD4 Antagonist and Histone Deacetylase Inhibitor Against Human Acute Myelogenous Leukemia Cells
Molecular Cancer Therapeutics
Cancer Research
Oncology
Bromodomain and Extraterminal (BET) Protein Inhibition Suppresses Human T Cell Leukemia Virus 1 (HTLV-1) Tax Protein-Mediated Tumorigenesis by Inhibiting Nuclear Factor κB (NF-κB) Signaling
Journal of Biological Chemistry
Biochemistry
Cell Biology
Molecular Biology
BET Bromodomain Inhibitors With One-Step Synthesis Discovered From Virtual Screen
Journal of Medicinal Chemistry
Drug Discovery
Molecular Medicine
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