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Publications by Jim C. Leeds

A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution

Molecular Biology

English

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MTORC1/2 Inhibition as a Therapeutic Strategy for PIK3CA Mutant Cancers

Molecular Cancer Therapeutics

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Mutant Kras Copy Number Defines Metabolic Reprogramming and Therapeutic Susceptibilities

Multidisciplinary

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MA27.06 Therapeutic Silencing of Oncogenic KRAS With a Mutant-Specific Short Interfering RNA

Journal of Thoracic Oncology

Respiratory Medicine

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Erratum: Mechanism of MEK Inhibition Determines Efficacy in Mutant KRAS- Versus BRAF-driven Cancers

Multidisciplinary

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Tissue of Origin Dictates Branched-Chain Amino Acid Metabolism in Mutant Kras-Driven Cancers

Multidisciplinary

Philosophy of Science

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Tumor Evolution as a Therapeutic Target

Cancer Discovery

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An in Vivo shRNA-Drug Screen to Identify Novel Targeted Therapy Combinations for KRAS Mutant Cancers

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A Recombinant Chimeric Protein Specifically Induces Mutant KRAS Degradation and Potently Inhibits Pancreatic Tumor Growth

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Allosteric Inhibitors Target KRAS in a Mutant-Specific Manner

Cancer Discovery

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