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Publications by Ladislau C. Kovari

Novel Protease Inhibitors Containing C-5-Modified Bis-THF and Aminobenzothiazole as P2 and P2′ Ligands That Exert Potent Antiviral Activity Against Highly Multidrug-Resistant HIV-1 With High Genetic Barrier Against the Emergence of Drug Resistance.

Antimicrobial Agents and Chemotherapy

Infectious Diseases

Pharmacology

2019

English

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C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, Including Darunavir

English

Flexible Cyclic Ethers/Polyethers as Novel P2-Ligands for HIV-1 Protease Inhibitors: Design, Synthesis, Biological Evaluation, and Protein−Ligand X-Ray Studies†

Journal of Medicinal Chemistry

Drug Discovery

Molecular Medicine

2008

English

Halogen Bond Interactions of Novel HIV-1 Protease Inhibitors (PI)(GRL-001-15 and GRL-003-15) With the Flap of Protease Are Critical for Their Potent Activity Against Wild-Type and Multi-Pi-Resistant HIV-1 Variants

Antimicrobial Agents and Chemotherapy

Infectious Diseases

Pharmacology

2019

English

Potent Activity Against Multidrug-Resistant Mycobacterium Tuberculosis of ^|^#945;-Mangostin Analogs

Chemical and Pharmaceutical Bulletin

English

Potent HIV‐1 Protease Inhibitors Containing Carboxylic and Boronic Acids: Effect on Enzyme Inhibition and Antiviral Activity and Protein‐ligand X‐ray Structural Studies

English

Novel P2 Tris-Tetrahydrofuran Group in Antiviral Compound1(GRL-0519) Fills the S2 Binding Pocket of Selected Mutants of HIV-1 Protease

Journal of Medicinal Chemistry

Drug Discovery

Molecular Medicine

2013

English

Structure-Based Design of Novel HIV-1 Protease Inhibitors to Combat Drug Resistance

English

187 Drug Resistance: Crystallography of Drug-Resistant HIV-1 Protease Mutant

Journal of Biomolecular Structure and Dynamics

English

Synthesis of Betulinic Acid Derivatives as Entry Inhibitors Against HIV-1 and Bevirimat-Resistant HIV-1 Variants

Bioorganic and Medicinal Chemistry Letters

Clinical Biochemistry

Pharmaceutical Science

Drug Discovery

2012

English

Amanote Research

Discover open access scientific publications

Search, annotate, share and cite publications

Publications by Ladislau C. Kovari

Novel Protease Inhibitors Containing C-5-Modified Bis-THF and Aminobenzothiazole as P2 and P2′ Ligands That Exert Potent Antiviral Activity Against Highly Multidrug-Resistant HIV-1 With High Genetic Barrier Against the Emergence of Drug Resistance.

Related publications

C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, Including Darunavir

Flexible Cyclic Ethers/Polyethers as Novel P2-Ligands for HIV-1 Protease Inhibitors: Design, Synthesis, Biological Evaluation, and Protein−Ligand X-Ray Studies†

Halogen Bond Interactions of Novel HIV-1 Protease Inhibitors (PI)(GRL-001-15 and GRL-003-15) With the Flap of Protease Are Critical for Their Potent Activity Against Wild-Type and Multi-Pi-Resistant HIV-1 Variants

Potent Activity Against Multidrug-Resistant Mycobacterium Tuberculosis of ^|^#945;-Mangostin Analogs

Potent HIV‐1 Protease Inhibitors Containing Carboxylic and Boronic Acids: Effect on Enzyme Inhibition and Antiviral Activity and Protein‐ligand X‐ray Structural Studies

Novel P2 Tris-Tetrahydrofuran Group in Antiviral Compound1(GRL-0519) Fills the S2 Binding Pocket of Selected Mutants of HIV-1 Protease

Structure-Based Design of Novel HIV-1 Protease Inhibitors to Combat Drug Resistance

187 Drug Resistance: Crystallography of Drug-Resistant HIV-1 Protease Mutant

Synthesis of Betulinic Acid Derivatives as Entry Inhibitors Against HIV-1 and Bevirimat-Resistant HIV-1 Variants