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Publications by Nicole S. Delino

The High Genetic Barrier of EFdA/MK-8591 Stems From Strong Interactions With the Active Site of Drug-Resistant HIV-1 Reverse Transcriptase

Cell Chemical Biology
Molecular MedicineMolecular BiologyPharmacologyBiochemistryClinical BiochemistryDrug Discovery
2018English

Novel Protease Inhibitors Containing C-5-Modified Bis-THF and Aminobenzothiazole as P2 and P2′ Ligands That Exert Potent Antiviral Activity Against Highly Multidrug-Resistant HIV-1 With High Genetic Barrier Against the Emergence of Drug Resistance.

Antimicrobial Agents and Chemotherapy
Infectious DiseasesPharmacology
2019English

Related publications

Exploring the Effects of Active Site Constraints on HIV-1 Reverse Transcriptase DNA Polymerase Fidelity

Journal of Biological Chemistry
BiochemistryCell BiologyMolecular Biology
2002English

Elucidating Molecular Interactions of L-Nucleotides With HIV-1 Reverse Transcriptase and Mechanism of M184v-Caused Drug Resistance

Communications Biology
GeneticsMolecular BiologyBiochemistryBiological SciencesMedicineAgricultural
2019English

The P66 Immature Precursor of HIV-1 Reverse Transcriptase

Proteins: Structure, Function and Genetics
BiochemistryStructural BiologyMolecular Biology
2014English

[D4U]-Spacer-[Hi-236] Double-Drug Inhibitors of HIV-1 Reverse-Transcriptase

Bioorganic and Medicinal Chemistry
Organic ChemistryMolecular MedicineMolecular BiologyBiochemistryClinical BiochemistryPharmaceutical ScienceDrug Discovery
2010English

Development of a Vaginal Delivery Film Containing EFdA, a Novel Anti-Hiv Nucleoside Reverse Transcriptase Inhibitor

International Journal of Pharmaceutics
Pharmaceutical Science
2014English

Biological Evaluation of Inhibitors of Reverse Transcriptase From HIV Type-1

Current Chemistry Letters
Chemistry
2015English

MK-8591 (4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine) Exhibits Potent Activity Against HIV-2 Isolates and Drug-Resistant HIV-2 Mutants in Culture

Antimicrobial Agents and Chemotherapy
Infectious DiseasesPharmacology
2017English

Interactions Between HIV-1 Reverse Transcriptase and the Downstream Template Strand in Stable Complexes With Primer-Template

PLoS ONE
Multidisciplinary
2008English

Probing the Molecular Mechanism of Action of the HIV-1 Reverse Transcriptase Inhibitor 4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine (EFdA) Using Pre-Steady-State Kinetics

Antiviral Research
VirologyPharmacology
2014English

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