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Publications by Rémi Opsomer

Influence of the Familial Alzheimer's Disease-Associated T43I Mutation on the Transmembrane Structure and Γ-Secretase Processing of the C99 Peptide

Journal of Biological Chemistry
BiochemistryCell BiologyMolecular Biology
2019English

Contribution of the Endosomal-Lysosomal and Proteasomal Systems in Amyloid-Β Precursor Protein Derived Fragments Processing

Frontiers in Cellular Neuroscience
Molecular NeuroscienceCellular
2018English

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A Presenilin 1 Mutation Associated With Familial Frontotemporal Dementia Inhibits Γ-Secretase Cleavage of APP and Notch

Neurobiology of Disease
Neurology
2002English

The Effects of Transmembrane Sequence and Dimerization on Cleavage of the P75 Neurotrophin Receptor by Γ-Secretase

Journal of Biological Chemistry
BiochemistryCell BiologyMolecular Biology
2012English

The Achilles Heel of Γ-Secretase: Can We Contain Alzheimer's Disease by Reducing Synthesis of Β-Amyloid?

Acta Pharmacologica Sinica
MedicinePharmacology
2010English

CD147 Is a Regulatory Subunit of the -Secretase Complex in Alzheimer's Disease Amyloid -Peptide Production

Proceedings of the National Academy of Sciences of the United States of America
Multidisciplinary
2005English

Modulation of Gamma-Secretase for the Treatment of Alzheimer's Disease

International Journal of Alzheimer's Disease
AgingCognitive NeuroscienceMolecular NeuroscienceNeurologyBehavioral NeuroscienceCellular
2012English

Mechanism of the Cleavage Specificity of Alzheimer's Disease -Secretase Identified by Phenylalanine-Scanning Mutagenesis of the Transmembrane Domain of the Amyloid Precursor Protein

Proceedings of the National Academy of Sciences of the United States of America
Multidisciplinary
1999English

Structure and Dynamics of Alzheimer's Associated Amyloid-Beta Peptide

Biophysical Journal
Biophysics
2019English

The Mechanism of Γ-Secretase

Journal of Biological Chemistry
BiochemistryCell BiologyMolecular Biology
2003English

Identification of Two Novel Synaptic Γ-Secretase Associated Proteins That Affect Amyloid Β-Peptide Levels Without Altering Notch Processing

Neurochemistry International
Molecular NeuroscienceCell BiologyCellular
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