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Publications by T. C. Appleby
Preclinical Characterization of GS-9669, a Thumb Site II Inhibitor of the Hepatitis C Virus NS5B Polymerase
Antimicrobial Agents and Chemotherapy
Infectious Diseases
Pharmacology
Related publications
Binding Site Characterization and Resistance to a Class of Non-Nucleoside Inhibitors of the Hepatitis C Virus NS5B Polymerase
Journal of Biological Chemistry
Biochemistry
Cell Biology
Molecular Biology
Characterization of Thiobarbituric Acid Derivatives as Inhibitors of Hepatitis C Virus NS5B Polymerase
Virology Journal
Virology
Infectious Diseases
Mechanism of Inhibition for BMS-791325, a Novel Non-Nucleoside Inhibitor of Hepatitis C Virus NS5B Polymerase
Journal of Biological Chemistry
Biochemistry
Cell Biology
Molecular Biology
Characterization of Resistance to the Protease Inhibitor GS-9451 in Hepatitis C Virus-Infected Patients
Antimicrobial Agents and Chemotherapy
Infectious Diseases
Pharmacology
Inhibition of Hepatitis C Virus NS5B Polymerase by S-Trityl-L-Cysteine Derivatives
European Journal of Medicinal Chemistry
Medicine
Organic Chemistry
Drug Discovery
Pharmacology
Thumb II Site Inhibitor Allosterically Suppresses the Dynamics of HCV RNA-Dependent RNA Polymerase
Biophysical Journal
Biophysics
Structural and Regulatory Elements of HCV NS5B Polymerase – Β-Loop and C-Terminal Tail – Are Required for Activity of Allosteric Thumb Site II Inhibitors
PLoS ONE
Multidisciplinary
Dynamics of Hepatitis C Virus (HCV) RNA-dependent RNA Polymerase NS5B in Complex With RNA
Journal of Biological Chemistry
Biochemistry
Cell Biology
Molecular Biology
Activity of a Potent Hepatitis C Virus Polymerase Inhibitor in the Chimpanzee Model
Antimicrobial Agents and Chemotherapy
Infectious Diseases
Pharmacology
