Discover open access scientific publications

Search, annotate, share and cite publications

Publications by T. Iwatsubo

Cooperative Roles of Hydrophilic Loop 1 and the C-Terminus of Presenilin 1 in the Substrate-Gating Mechanism of -Secretase

Journal of Neuroscience

English

Lentiviral Vector Delivery of Parkin Prevents Dopaminergic Degeneration in an -Synuclein Rat Model of Parkinson's Disease

Proceedings of the National Academy of Sciences of the United States of America

Multidisciplinary

English

Related publications

The Extreme C Terminus of Presenilin 1 Is Essential for Γ-Secretase Complex Assembly and Activity

Journal of Biological Chemistry

Molecular Biology

English

Cell Surface Presenilin-1 Participates in the Γ-Secretase-Like Proteolysis of Notch

Journal of Biological Chemistry

Molecular Biology

English

Comparison of Presenilin 1 and Presenilin 2 Γ-Secretase Activities Using a Yeast Reconstitution System

Journal of Biological Chemistry

Molecular Biology

English

Molecular Mechanism of Dream -Presenilin-1 Interactions

Biophysical Journal

English

Fatty Acids Increase Presenilin-1 Levels and Γ-Secretase Activity in PSwt-1 Cells

Journal of Lipid Research

English

Activation of Γ-Secretase Trimming Activity by Topological Changes of Transmembrane Domain 1 of Presenilin 1

Journal of Neuroscience

English

Presenilin-1 and -2 Are Molecular Targets for Γ-Secretase Inhibitors

Journal of Biological Chemistry

Molecular Biology

English

Structural Investigation of the C-Terminal Catalytic Fragment of Presenilin 1

Proceedings of the National Academy of Sciences of the United States of America

Multidisciplinary

English

Proteolytic Processing of the Alzheimer Disease-Associated Presenilin-1 Generates an in Vivo Substrate for Protein Kinase C

Proceedings of the National Academy of Sciences of the United States of America

Multidisciplinary

English