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Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)5,8-Dichloro-7-(Methoxy(oxetan-3-Yl)methyl)-2-((4-Methoxy-6-Methyl-2-Oxo-1,2-Dihydropyridin-3-Yl)methyl)-3,4-Dihydroisoquinolin-1(2H)one (PF-06821497)
Synthesis and Anion Binding Properties of N, N-Bispyrrol-2-Yl-2, 5-Diamidopyrrole
CuI-Mediated Synthesis of Sulfonyl Benzofuran-3-Ones and Chroman-4-Ones
4-Alkoxy-1,1,1-Trihalo-3-Alken-2-Ones as Building Blocks for Trihalomethylated Heterocycles. Synthesis of 4-Trihalomethyl-2-Pyrimidinones
Journal of the Brazilian Chemical Society
Chemistry
Discovery and Optimization of Sulfonyl Acrylonitriles as Selective, Covalent Inhibitors of Protein Phosphatase Methylesterase-1
Journal of Medicinal Chemistry
Drug Discovery
Molecular Medicine
The Synthesis and Ion-Exchange Properties of TiH2(PO4)2·1/2H2O
Bulletin of the Chemical Society of Japan
Chemistry
Improved Synthesis of 5-Aryl-2-Thioxoimidazolidin-4-Ones From Arylglyoxals Hydrates
European Chemical Bulletin
Chemistry
Synthesis of 1, 3-Diaryl-2-Propene-1-One Derivatives Using Tripotassium Phosphate as an Alternative and Efficient Catalyst and Study Its Cytotoxic and Antimicrobial Properties
Current Chemistry Letters
Chemistry
Synthesis of Stereodefined 1-Aryl(heteroaryl) Substituted 1,2-Bis(2-Bromopyridin-3-Yl)ethenes by Selective Tandem Suzuki–Miyaura Cross-Coupling Reactions
Tetrahedron Letters
Organic Chemistry
Biochemistry
Drug Discovery
Design, Synthesis, and Biological Evaluation of Estrone-Derived Hedgehog Signaling Inhibitors
Tetrahedron
Organic Chemistry
Biochemistry
Drug Discovery
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