Hepatocyte Growth Factor Renders BRAF Mutant Human Melanoma Cell Lines Resistant to PLX4032 by Downregulating the Pro-Apoptotic BH3-only Proteins PUMA and BIM

Cell Death and Differentiation- United Kingdom

doi 10.1038/cdd.2016.96

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September 30, 2016

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Springer Science and Business Media LLC

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Hepatocyte Growth Factor Renders BRAF Mutant Human Melanoma Cell Lines Resistant to PLX4032 by Downregulating the Pro-Apoptotic BH3-only Proteins PUMA and BIM

Cell Death and Differentiation- United Kingdom

Full Text

Abstract

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Date

Authors

Publisher

Related search

Granulocyte/Macrophage Colony–Stimulating Factor Causes a Paradoxical Increase in the BH3-Only Pro-Apoptotic Protein Bim in Human Neutrophils

Genetic Variants of a BH3-only Pro-Apoptotic Gene,PUMA, and Risk of HPV16-associated Squamous Cell Carcinoma of the Head and Neck

The NF- B Regulator BCL-3 and the BH3-only Proteins Bim and Puma Control the Death of Activated T Cells

Expression of Bbc3, a Pro-Apoptotic BH3-only Gene, Is Regulated by Diverse Cell Death and Survival Signals

Puma Cooperates With Bim, the Rate-Limiting BH3-only Protein in Cell Death During Lymphocyte Development, in Apoptosis Induction

Comparison of Responses of Human Melanoma Cell Lines to MEK and BRAF Inhibitors

The BCL-2 Homology Domain 3 (BH3)-only Proteins Bim and Bid Are Functionally Active and Restrained by Anti-Apoptotic BCL-2 Family Proteins in Healthy Liver

Bim Controls IL-15 Availability and Limits Engagement of Multiple BH3-only Proteins

Inhibitors of Pan-Pi3k Signaling Synergize With BRAF or MEK Inhibitors to Prevent BRAF-Mutant Melanoma Cell Growth