(PDF) Application of the Goldilocks Effect to the Design of

Application of the Goldilocks Effect to the Design of Potent and Selective Inhibitors of Phenylethanolamine N-Methyltransferase: Balancing pKa and Steric Effects in the Optimization of 3-Methyl-1, 2, 3, 4-Tetrahydroisoquinoline Inhibitors by B-Fluorination

doi 10.1021/jm051262k.s001

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Application of the Goldilocks Effect to the Design of Potent and Selective Inhibitors of Phenylethanolamine N-Methyltransferase: Balancing pKa and Steric Effects in the Optimization of 3-Methyl-1, 2, 3, 4-Tetrahydroisoquinoline Inhibitors by B-Fluorination

doi 10.1021/jm051262k.s001

Full Text

Abstract

Date

Authors

Publisher

Related search

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Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3)

Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3)

Optimization of Subsite Binding to the B5 Subunit of the Human 20S Proteasome Using Vinyl Sulfones and 2-Keto-1, 3, 4-Oxadiazoles: Syntheses and Cellular Properties of Potent, Selective Proteasome Inhibitors

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