Toward Optimization of the Second Aryl Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies†

Journal of Medicinal Chemistry - United States
doi 10.1021/jm801347s
Full Text
Abstract

Available in full text

Date
Authors
Publisher

American Chemical Society (ACS)

Related search

Sulfated Glycosaminoglycans Accelerate Transthyretin Amyloidogenesis by Quaternary Structural Conversion

Biochemistry
Biochemistry
2011English

Native State Stabilization by NSAIDs Inhibits Transthyretin Amyloidogenesis From the Most Common Familial Disease Variants

Laboratory Investigation
Forensic MedicinePathologyCell BiologyMolecular Biology
2004English

AG10 Inhibits Amyloidogenesis and Cellular Toxicity of the Familial Amyloid Cardiomyopathy-Associated V122I Transthyretin

Proceedings of the National Academy of Sciences of the United States of America
Multidisciplinary
2013English

Aero-Structural Optimization of the NASA Common Research Model

2017English

Identification of Transthyretin Fibril Formation Inhibitors Using Structure-Based Virtual Screening

ChemMedChem
Organic ChemistryMolecular MedicinePharmacologyBiochemistryToxicologyDrug DiscoveryPharmaceutics
2017English

Novel Transthyretin Amyloid Fibril Formation Inhibitors: Synthesis, Biological Evaluation, and X-Ray Structural Analysis

PLoS ONE
Multidisciplinary
2009English

Biochemical and Structural Analysis of Inhibitors Targeting the ADC-7 Cephalosporinase ofAcinetobacter Baumannii

Biochemistry
Biochemistry
2014English

Structural Optimization of Α-Synuclein Fibril Growth Inhibitors

Biophysical Journal
Biophysics
2019English

Spacer Asn Determines the Fate of Kunitz (STI) Inhibitors, as Revealed by Structural and Biochemical Studies on WCI Mutants

English

Amanote Research

Note-taking for researchers

Follow Amanote

© 2024 Amaplex Software S.P.R.L. All rights reserved.

Privacy PolicyRefund Policy