Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

Science - United States
doi 10.1126/science.1179386
Full Text
Abstract

Available in full text

Date
Authors
Publisher

American Association for the Advancement of Science (AAAS)

Related search

CDK7 Inhibition Suppresses Aberrant Hedgehog Pathway and Overcomes Resistance to Smoothened Antagonists

Proceedings of the National Academy of Sciences of the United States of America
Multidisciplinary
2019English

A Novel Nonsense Mutation in Androgen Receptor Confers Resistance to CYP17 Inhibitor Treatment in Prostate Cancer

Oncotarget
Oncology
2016English

Nonclassical Activation of Hedgehog Signaling Enhances Multidrug Resistance and Makes Cancer Cells Refractory to Smoothened-Targeting Hedgehog Inhibition

Journal of Biological Chemistry
BiochemistryCell BiologyMolecular Biology
2013English

Statins Synergize With Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma

Clinical Cancer Research
Cancer ResearchOncology
2018English

Structural Basis of Smoothened Activation in Hedgehog Signaling

Cell
BiochemistryGeneticsMolecular Biology
2018English

Targeting the Hedgehog Pathway to Mitigate Treatment Resistance

Cell Cycle
MedicineDevelopmental BiologyCell BiologyMolecular Biology
2007English

P53 Function Is Compromised by Inhibitor 2 of Phosphatase 2A in Sonic Hedgehog Medulloblastoma

Molecular Cancer Research
Cancer ResearchOncologyMolecular Biology
2018English

An Insertion Mutation of ERBB2 Enhances Breast Cancer Cell Growth and Confers Resistance to Lapatinib Through AKT Signaling Pathway

Biology Open
BiochemistryAgriculturalGeneticsMolecular BiologyBiological Sciences
2020English

A Rare Gain of Function Mutation in a Wheat Tandem Kinase Confers Resistance to Powdery Mildew

Nature Communications
AstronomyGeneticsMolecular BiologyBiochemistryChemistryPhysics
2020English

Amanote Research

Note-taking for researchers

Follow Amanote

© 2024 Amaplex Software S.P.R.L. All rights reserved.

Privacy PolicyRefund Policy