Nonclassical Activation of Hedgehog Signaling Enhances Multidrug Resistance and Makes Cancer Cells Refractory to Smoothened-Targeting Hedgehog Inhibition

Journal of Biological Chemistry- United States

doi 10.1074/jbc.m112.432302

Full Text

Abstract

Available in

Date

Authors

Publisher

American Society for Biochemistry & Molecular Biology (ASBMB)

Related search

Structural Basis of Smoothened Activation in Hedgehog Signaling

Cell
BiochemistryGeneticsMolecular Biology
2018English

CDK7 Inhibition Suppresses Aberrant Hedgehog Pathway and Overcomes Resistance to Smoothened Antagonists

Proceedings of the National Academy of Sciences of the United States of America
Multidisciplinary
2019English

Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

Science
MultidisciplinaryPhilosophy of ScienceHistory
2009English

Targeting the Hedgehog Pathway to Mitigate Treatment Resistance

Cell Cycle
MedicineDevelopmental BiologyCell BiologyMolecular Biology
2007English

Hedgehog Signaling Inhibition by Smoothened Antagonist BMS-833923 Reduces Osteoblast Differentiation and Ectopic Bone Formation of Human Skeletal (Mesenchymal) Stem Cells

Stem Cells International
Cell BiologyMolecular Biology
2019English

SUMO Regulates the Activity of Smoothened and Costal-2 in Drosophila Hedgehog Signaling

Scientific Reports
Multidisciplinary
2017English

Inhibition of Ciliogenesis Promotes Hedgehog Signaling, Tumorigenesis, and Metastasis in Breast Cancer

Molecular Cancer Research
Cancer ResearchOncologyMolecular Biology
2017English

Osteoblast-Secreted Collagen Upregulates Paracrine Sonic Hedgehog Signaling by Prostate Cancer Cells and Enhances Osteoblast Differentiation

Molecular Cancer
Cancer ResearchOncologyMolecular Medicine
2012English

Hedgehog Signaling Pathway in Ovarian Cancer

International Journal of Molecular Sciences
Organic ChemistryMolecular BiologyTheoretical ChemistryInorganic ChemistryComputer Science ApplicationsSpectroscopyMedicineCatalysisPhysical
2013English

Amanote Research

Note-taking for researchers

Follow Amanote

© 2026 Amaplex Software S.P.R.L. All rights reserved.

Privacy PolicyRefund Policy