Deficiency of Neuronal P38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models Through Facilitating Lysosomal Degradation of BACE1

Journal of Biological Chemistry - United States
doi 10.1074/jbc.m115.695916
Full Text
Abstract

Available in full text

Date
Authors
Publisher

American Society for Biochemistry & Molecular Biology (ASBMB)

Related search

DNA Aptamers Targeting BACE1 Reduce Amyloid Levels and Rescue Neuronal Deficiency in Cultured Cells

Molecular Therapy - Nucleic Acids
Drug DiscoveryMolecular Medicine
2019English

Lack of BACE1 S-Palmitoylation Reduces Amyloid Burden and Mitigates Memory Deficits in Transgenic Mouse Models of Alzheimer’s Disease

Proceedings of the National Academy of Sciences of the United States of America
Multidisciplinary
2017English

Myo-Inositol Changes Precede Amyloid Pathology and Relate toAPOEgenotype in Alzheimer Disease

Neurology
Neurology
2016English

Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing a Generation and Amyloid Plaque Pathogenesis

Journal of Neuroscience
Neuroscience
2015English

Impact of RTN3 Deficiency on Expression of BACE1 and Amyloid Deposition

Journal of Neuroscience
Neuroscience
2014English

P-Glycoprotein Deficiency at the Blood-Brain Barrier Increases Amyloid- Deposition in an Alzheimer Disease Mouse Model

Journal of Clinical Investigation
Medicine
2005English

P38α-Mapk Signaling Inhibition Attenuates Soleus Atrophy During Early Stages of Muscle Unloading

International Journal of Molecular Sciences
Organic ChemistryMolecular BiologyTheoretical ChemistryInorganic ChemistryComputer Science ApplicationsSpectroscopyMedicineCatalysisPhysical
2020English

Lysosomal NEU1 Deficiency Affects Amyloid Precursor Protein Levels and Amyloid-Β Secretion via Deregulated Lysosomal Exocytosis

Nature Communications
AstronomyGeneticsMolecular BiologyBiochemistryChemistryPhysics
2013English

Review: Experimental Manipulations of Microglia in Mouse Models of Alzheimer's Pathology: Activation Reduces Amyloid but Hastens Tau Pathology

Neuropathology and Applied Neurobiology
Forensic MedicinePathologyNeurologyHistologyPhysiology
2013English

Amanote Research

Note-taking for researchers

Follow Amanote

© 2024 Amaplex Software S.P.R.L. All rights reserved.

Privacy PolicyRefund Policy