(PDF) Weak Domain Stability and Higher Ca 2+ Binding

Weak Domain Stability and Higher Ca 2+ Binding Affinity Contribute to Allostery Between the D/E Linker and N-Helix of Cardiac Troponin C

Biophysical Journal - United States

doi 10.1016/j.bpj.2017.11.2336

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Date

February 1, 2018

Authors

Guilherme A.P. de Oliveira

Publisher

Elsevier BV

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Weak Domain Stability and Higher Ca 2+ Binding Affinity Contribute to Allostery Between the D/E Linker and N-Helix of Cardiac Troponin C

Biophysical Journal - United States

doi 10.1016/j.bpj.2017.11.2336

Full Text

Abstract

Categories

Date

Authors

Publisher

Related search

Dynamic and Structural Allosteric Events Between the D/E Linker and N-Domain of Cardiac Troponin C Reveal a Novel Mechanism for Cardiac Muscle Regulation

A Novel DCM-Associated Mutation in the N-Helix of Cardiac Troponin C Exhibits Impaired Contractile Kinetics and Reduced Ca 2+ -Sensitivity in Vitro

Structure of the Regulatory N-Domain of Human Cardiac Troponin C in Complex With Human Cardiac Troponin I147–163and Bepridil

Effects of PKA Phosphorylation of Cardiac Troponin I and Strong Crossbridge on Conformational Transitions of the N-Domain of Cardiac Troponin C in Regulated Thin Filaments†

Structure of the Inhibitor W7 Bound to the Regulatory Domain of Cardiac Troponin C

On the Ca 2+ Binding and Conformational Change in EF-hand Domains: Experimental Evidence of Ca 2+ -Saturated Intermediates of N-Domain of Calmodulin

Functional Significance of C-Terminal Mobile Domain of Cardiac Troponin I

Designing Calcium-Sensitizing Mutations in the Regulatory Domain of Cardiac Troponin C

Localization of the 12.6-kDa FK506-binding Protein (FKBP12.6) Binding Site to the NH 2 -Terminal Domain of the Cardiac Ca 2+ Release Channel (Ryanodine Receptor)