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Publications by Laure Mendes da Costa

Pharmacokinetic and Pharmacodynamic Effects of a Γ‐secretase Modulator, PF‐06648671, on CSF Amyloid‐β Peptides in Randomized Phase 1 Studies

Clinical Pharmacology and Therapeutics

English

Related publications

The Role of Γ-Secretase Activating Protein (GSAP) and Imatinib in the Regulation of Γ-Secretase Activity and Amyloid-Β Generation

Journal of Biological Chemistry

Molecular Biology

English

Pharmacodynamic and Pharmacokinetic Studies of Β-Cyclodextrin:Dexamethasone Acetate Complexes in Mice

Brazilian Archives of Biology and Technology

English

Β-Secretase Cleavage at Amino Acid Residue 34 in the Amyloid Β Peptide Is Dependent Upon Γ-Secretase Activity

Journal of Biological Chemistry

Molecular Biology

English

Equimolar Production of Amyloid Β-Protein and Amyloid Precursor Protein Intracellular Domain From Β-Carboxyl-Terminal Fragment by Γ-Secretase

Journal of Biological Chemistry

Molecular Biology

English

Modulation of Γ-Secretase Reduces Β-Amyloid Deposition in a Transgenic Mouse Model of Alzheimer's Disease

English

The Transmembrane Aspartates in Presenilin 1 and 2 Are Obligatory for Γ-Secretase Activity and Amyloid Β-Protein Generation

Journal of Biological Chemistry

Molecular Biology

English

Intramembrane Proteolysis of Β-Amyloid Precursor Protein by Γ-Secretase Is an Unusually Slow Process

Biophysical Journal

English

APLP1 as a Cerebrospinal Fluid Biomarker for Γ-Secretase Modulator Treatment

Alzheimer's Research and Therapy

Cognitive Neuroscience

English

A Γ-Secretase Inhibitor, but Not a Γ-Secretase Modulator, Induced Defects in BDNF Axonal Trafficking and Signaling: Evidence for a Role for APP

Multidisciplinary

English