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Publications by Richard Kennan
A Brain Penetrant Mutant IDH1 Inhibitor Provides in Vivo Survival Benefit
Scientific Reports
Multidisciplinary
Effects of Carvedilol on Structural and Functional Outcomes and Plasma Biomarkers in the Mouse Transverse Aortic Constriction Heart Failure Model
SAGE Open Medicine
Medicine
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A Brain-Penetrant MET Inhibitor Achieves Responses in Glioblastoma
Cancer Discovery
Oncology
The Brain-Penetrant Clinical ATM Inhibitor AZD1390 Radiosensitizes and Improves Survival of Preclinical Brain Tumor Models
Science advances
Multidisciplinary
Combination Treatment of an IDH1 Inhibitor With Chemotherapy in IDH1 Mutant Acute Myeloid Leukemia
Annals of Hematology
Medicine
Hematology
Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity
Structure
Structural Biology
Molecular Biology
Structure Based Discovery of Clomifene as a Potent Inhibitor of Cancer-Associated Mutant IDH1
Oncotarget
Oncology
Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression
Molecular Cancer Research
Cancer Research
Oncology
Molecular Biology
Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate
Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR
Mutant IDH1 and Seizures in Patients With Glioma
Neurology
Neurology
